A.   期刊論文 (*Corresponding author)

1

Lin, J.Y.*, Hsieh, Y.S., and Chu, S.C. (1987) The isolation and purification of pre-S2 containing hepatitis B virus surface antigen by  chemical affinity chromatography.  Applied Biochemistry and Biotechnology 15: 255-263. (SCI)

2

Lin J.Y.*, Hsieh, Y.S., and Chu, S.C. (1989) Chimeric protein: abrin B chain-trypsin inhibitor conjugate as a new antitumor agent. Biochemistry International 19: 313-323. (SCI)

3

Lin J.Y.*, Chu, S.C. , Wu, H.C., and Hsieh, Y.S. (1991) Trypsin inhibitor from the seeds of Acacia confusa. Journal of Biochemistry 110: 879-883. (SCI)

4

 Chu, S.C. , Hsieh, Y.S., and Lin J.Y.* (1992) Inhibitory effects of flavonoids on Moloney murine leukemia virus reverse transcriptase activity. Journal of Natural Products 55: 179-183. (SCI)

5

Chu, S.C. , Chen, Y.J., Wang, L., Liu, C.P., Chiang, W.L., and Hsieh, Y.S.* (1994) Antimutagenic effect of extracts of Chinese medicine herbs on N-methyl-N-nitro-N- nitrosoguanidine and 2-aminoflourene.  J. Biomed. Lab. Sci. 6: 35-42.

6

Tahirov, T.H.*, Lu, T.H., Liaw, Y.C., Chu, S.C. , and Lin, J.Y. (1994) A new crystal form of abrin-a from the seeds of Abrus precatorius.  Journal of Molcular Biology 235: 1152-1153. (SCI)

7

Yen, J.H., Chang, S.C., Hu, C.R., Chu, S.C., Lin, S.S., Hsieh, Y.S., and Chang, M.F.* (1995) Cellular proteins specifically bind to the 5’-noncoding region of hepatitis C virus RNA. Virology 208: 723-732. (SCI)

8

Chu, S.C. , Chou, F.P., Liu, J.Y., Lin, L.J., and Hsieh, Y.S.* (1997) Proteolytic activity of mouse sarcoma 180 cells that are inhibited by Bowman-Birk and Kunitz protease inhibitors. Biochemistry and Molecular Biology International 42: 965-975. (SCI)

9

Chiang, W.L., Lai, J.C., Tasy, Y.T., Liu, J.Y., Chu, S.C. , and Hsieh, Y.S.* (1999) Quantification of superoxide dismutase, glutathione peroxidase and total antioxidant capacity in blood of healthy Taiwanese by a modified automated procedure. J. Biomedi. Lab. Sci. 11: 29-36.

10

Chu, S.C. , Chou, Y.C., Liu, J.Y., Chen, C.H., Shyu, J.C., and Chou, F.P.* (1999) Fluctuation of serum leptin level in rats after ovariectomy and the influence of estrogen supplement. Life Science 64: 2299-2306. (SCI)

11

Kuo, W.H., Chou, F.P., Lu, S.C., Chu, S.C. , and Hsieh, Y.S.* (2000) Significant differences in serum of matrix metalloprotease-2 and –9 between HCV- and HBV-infected patients and carriers. Clinica Chimica Acta 294: 157-168. (SCI)

12

Chiang, W.L., Chu, S.C. , Lai, J.C., Yang, S.F, Chiou H.L., and Hsieh, Y.S.* (2001) Alternations in quantities and activities of erythrocyte cytosolic carbonic anhydrase isoenzymes in glucose-6-phosphate dehydrogenase-deficiency individuals. Clinica Chimica Acta 314: 195-201. (SCI)

13

Chou, F.P., Chu, S.C. , Cheng, M.C., Yang, S.F., Cheung, W.N., Chiou, H.L., and Hsieh, Y.S.* (2002) Effect of hemodialysis on the plasma level of type IV collagenases and their inhibitors. Clinical Biochemistry 35: 383-388. (SCI)

14

Chiang, W.L., Chu, S.C., Yang , S.S., Li, M.C. Lai, J.C, Yang, S.F., Chiou, H.L., and Hsieh, Y.S.* (2002) The aberrant expression of cytosolic carbonic anhydrase and its clinical significance in human non-small cell lung cancer. Cancer Letters 188: 199-205. (SCI)

15

.Kuo, W.H., Yang, S.F., Chu, S.C., Lu, S.C., Chou, F.P., and Hsieh, Y.S.* (2003) Differential inductions of matrix metalloproteinase-2 and -9 in host tissues during the growth of ascitic sarcoma 180 cells in mice. Cancer Letters 189: 103-112. (SCI)

16

Kuo, W.H., Chiang, W.L., Yang, S.F., Yeh, C.T., Yeh, C.M., Hsieh, Y.S., and Chu, S.C. * (2003) The differential expression of cytosolic carbonic anhydrase in human hepatocellular carcinoma. Life Science 73: 2211-2223. (SCI)

17

Chu, S.C. , Yang, S.F., Lue, K.H., Hsieh, Y.S., Hsiao, T.Y., and Lu , K.H.* (2004) The clinical significance of gelatinase B in gouty arthritis of the knee. Clinica Chimica Acta 339: 77-83. (SCI)

18

Lu, K.H., Yang, S.F., Chu, S.C. , Chen, P.N., Chou, M.C., Hsiao, T.Y., and Hsieh, Y.S.* (2004) The significance of altered gelatinases expression in the synovium of patient with arthritic effusions. Clinical Rheumatology 23: 21-26. (SCI)

19

Chu, S.C. , Wang, C.P., Chang, Y.H., Hsieh, Y.S., Yang, S.F., Su, J.M., Lin, K.L., and Chiou, H.L.* (2004) Increased cystatin C serum concentrations in patients with hepatic diseases of various severities. Clinica Chimica Acta 341: 133-138. (SCI)

20

Hsieh, Y.S., Yang, S.F., Chu, S.C. , Chen, P.N., Chou, M.C., Hsu, M.C., and Lu, K.H.* (2004) Expression changes of gelatinases in human osteoarthritic knee and the arthroscopic débridement. Arthroscopy 20: 482-488. (SCI)

21

Chang, Y.C., Chu, S.C. , Yang, S.F., Hsieh, Y.S., Yang, L.C., and Huang, F.M.* (2004) Examination of the signal transduction pathways leading to activation of gelatinolytic activity by interleukin-1 and Prophyromonas giingivalis in human osteosarcoma cells. Journal of Periodontal Research 39: 168-174. (SCI)

22

Chu, S.C. , Chiou, H.L., Chen, P.N., Yang, S.F., and Hsieh, Y.S.* (2004) Silibinin inhibit the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Molecular Carcinogenesis 40: 143-149. (SCI)

23

Chu, S.C. , Tsai, C.H., Yang, S.F., Huang, F.M., Su, Y.F., Hsieh, Y.S., and Chang, Y.C. * (2004) Induction of vascular endothelial growth factor gene expression by proinflammatory cytokines in human pulp and gingival fibroblast. Journal of Endodontics 30: 704-707. (SCI)

24

Chiang, W.L., Liu, J.Y., Liao, C.Y., Yang, S.F., Hsieh, Y.S., and Chu, S.C. * (2004) Alternation cytosolic carbonic anhydrase isoenzymes during deciduomatal development in pregnant mice. Fertility and Sterility 82 (Suppl 3): 1095-1100. (SCI)

25

Chu, S.C. , Yang, S.F., Lue, K.H., Hsieh, Y.S., Hsu, M.C., and Lu, K.H.* (2004) Regulation of gelatinases expression by cytokines, endotoxins and pharmacological agents in the human osteoarthritic knee. Connective Tissue Research 45: 142-150. (SCI)

26

Chu, S.C. , Yang, S.F. Lue, K.H., Hsieh, Y.S. Lin Z. I., and Lu, K.H.* (2004) Clinical significance of gelatinases in septic arthritis of the native and replaced knees. Clinical Orthopaedics and Related Research 427: 179-183. (SCI)

27

Chu, S.C., Hu, D.N.*, Yang, S.F., Yang, P.Y., Hsieh, Y.S., and McCormick, S.A. (2004) Uveal melanocytes produce matrix metalloproteinase-2 and –9 in vitro. Pigment Cell Res. 17: 636-642. (SCI)

28

Tsai, C.H., Yang, S.F., Chen,Y. J., Chu, S.C., Hsieh, Y.S., and Chang, Y. C.* (2004) Regulation of interleukin-6 expression by arecoline in human buccal fibroblasts is related to intracellular glutathione levels. Oral Disease 10: 360-364. (SCI)

29

Kuo, W.H., Yang, S.F., Hsieh, Y.S., Tsai, C.H., Hwang, W.L., and Chu, S.C. * (2005) Differential expression of carbonic anhydrase isoenzymes in various types of anemia. Clinica Chimica Acta 351: 79-86. (SCI)

30

Yang, S.F., Chu, S.C., Chiang, I.C., Kuo, W.F., Chiou, H.L., Chou, F.P., Kuo, W.H., and Hsieh, Y.S.* (2005) Excessive matrix metalloproteinase-9 in the plasma of community- acquired pneumonia. Clinica Chimica Acta 352: 209-215. (SCI)

31

Yang, S.F., Hsieh, Y.S., Lin, C.L., Hsu, N.Y., Chiou, H.L., Chou, F.P., and Chu, S.C.* (2005) Increased plasma levels of urokinase plasminogen activator and matrix metalloproteinase-9 in nonsmall cell lung cancer patients. Clinica Chimica Acta 354: 91-99. (SCI)

32

Chen, P.N., Chiou, H.L., Chu, S.C., Chiang, C.L., Wang, J.C., and Hsieh, Y.S.* (2005) Anthocyanins inhibit the invasion of human lung carcinoma A549 cells via supressed activities of urokinase-plasminogen activator and matrix metalloproteinase-2.  Chung Shan Medical Journal 16: 23-36.

33

Chen, P.N., Hsieh, Y.S., Chiou, H.L., and Chu, S.C.* (2005) Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chemico-Biological Interactions 156: 141-150. (SCI)

34

Chen, P.N., Chu, S.C, Chiou, H.L.., Chiang, C.L., Yang S.F., and Hsieh, Y.S.* (2005) Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppresses tumor growth in vivo. Nutrition and Cancer 53:232-243 (SCI) Contributed equally as first author

35

Chu, S.C. , Yang, S.F., Lue, K.H., Hsieh, Y.S., Hsiao, T.Y., and Lu, K.H*. (2006) Urokinase-type plasminogen activator, receptor and inhibitor correlating with gelatinase-B (MMP-9) contributes to the inflammation in gouty arthritis of the knee. Journal of Rheumatology 33: 311-317. (SCI)

36

Chen, P.N., Hsieh, Y.S., Chiang, C. L., Chiou, H.L., Yang S.F., and Chu, S.C.*  (2006) Silibinin inhibits invasion of oral cancer cells by suppressing MAPK pathway. Journal of Dental Research 85: 220-225. (SCI)

37

Chen, P.N., Chu, S.C., Chiou, H.L. Chiang, C.L., Kuo, W.H., and Hsieh, Y.S.* (2006) Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Letters 235: 248-259. (SCI)

38

Chu, S.C. , Yang, S.F., Lue, K.H., Hsieh, Y.S., Lee, C.Y., Chou, M.C., and Lu, K.H* (2006) Glucosamine sulphate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. Clinica Chimica Acta 372: 167-172. (SCI)

39

Chen, P.N., Kuo, W.H., Chiang, C.L., Chiou, H.L., Hsieh, Y.S.,* and Chu, S.C. * (2006) Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. Chemico-Biological Interactions 163: 218-229. (SCI)

40

Chiang, W.L., Hsieh, Y.S., Yang, S.F., Lu, T.A., and Chu, S.C.* (2007) Differential expression of glutathione-S-transferase isoenzymes in various types of anemia in . Clinica Chimica Acta 375: 110-114. (SCI)

41

Hsiao, Y.C., Hsieh, Y.S., Kuo, W.H., Chiou, H.L., Yang, S.F., and Chu, S.C.* (2007) The tumor-growth inhibitory activity of flavanone and 2’-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs. Journal of Biomedical Science 14: 107-119.  (SCI)

42

Yang, S.F., Chu, S.C. , Liu, S.J., Chen, Y.C., Chang, Y.Z., and Hsieh, Y.S.* (2007) Antimetastatic activities of Selaginella tamariscina on lung cancer cells in vitro and in vivo. Journal of Ethnopharmacology 110: 483-489. (SCI)

43

Hsieh, Y.S., Yang, S.F., Lue, K.H., Chu, S.C. , and Lu, K.H.* (2007) Upregulation of urokinase-type plasminogen activator and inhibitor and gelatinases expression via three MAPKs and PI3K pathways during the early development of osteoarthritis. Journal of Rheumatology 110: 483-489. (SCI)

44

Hsieh, Y.S., Chu, S.C., Yang, S.F., Liu, Y.C., and Lu, K.H* (2007) Silibinin suppresses cell adhesion and invasion by changing cell morphology and inhibiting the FAK to ERK-dependent c-Jun/AP-1 induction of u-PA and MMP-2 in human osteosarcoma MG-63 cells. Carcinogenesis 28: 977-987. (SCI)

45

Hsiao, Y.C., Kuo, W.H., Chen, P.N., Chang, H.R., Lin, T.H., Yang, W.E., Hsieh, Y.S.*, and Chu, S.C. * (2007) Flavanone and 2’-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chemico-Biological Interactions 167: 193-206. (SCI)

46

Hsieh, Y.S., Yang, S.F., Liu, S.J., Chang, Y.Z., Chen, Y.C., Chiang, C.L., and Chu, S.C. * (2007) In vitro and in vivo antimetastatic effects of Terminalia catappa L. leaves on lung cancer cells. Food and Chemical Toxicology 45: 1194-201. (SCI)

47

Hsieh, Y.S., Yang, S.F., Chu, S.C. , and Kuo, D.Y. (2007) Transcript of protein kinase A knock-down modulates feeding behavior and neuropeptide Y gene expression in phenylpropanolamine-treated rats. Physiological Genomics 31:306-314. (SCI)

48

Hsieh, Y.S., Kuo, W.H., Lin, T.W., Chang, H.R., Lin, T.H., Chen, P.N. and Chu, S.C. * (2007) Protective effects of berberine against LDL oxidation and oxidized LDL-induced cytotoxicity on endothelial cells. Journal of Agricultural and Food Chemistry 55: 10437-10445. (SCI)

49

Yang, S.F., Hsieh. Y.S., Lue, K.H., Chu, S.C., Chang, I.C., and Lu, K.H. (2008) Effects of nonsteroidal antiinflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans. Clinical Biochemistry 41: 109-116. (SCI)

50

Chu, S.C. , Yang, S.F., Lue, K.H., Hsieh, Y.S., Chang, I.C., and Lu, K.H.* (2008) Naproxen, meloxicam and methylprednisolone inhibit urokinase plasminogen activator and inhibitor and gelatinases expression during the early stage of osteoarthritis. Clinica Chimica Acta 387: 90-96. (SCI)

51

Hsieh, Y.S., Yang, S.F., Chu, S.C. , and Kuo, D.Y*. (2008) Interrupting activator protein-1 signaling in conscious rats can modify neuropeptide Y gene expression and feeding behavior of phenylpropanolamine. Journal of Neurochemistry 104:50-61. (SCI)

52

Yang, S.F., Yang, W.E., Kuo, W.H., Chang, H.R., Chu, S.C. , Hsieh, Y.S*. (2008) Antimetastatic potentials of flavones on oral cancer cell via an inhibition of matrix-degrading proteases. Archives of Oral Biology 53: 287-94. (SCI)

53

Hsieh, Y.S., Yang, S.F., Lue, K.H., Chu, S.C. , and Lu, K.H.* (2008) Effects of different molecular weight hyaluronan products on the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. Journal of Orthopedic Research 26: 475-84. (SCI)

54

Chang, H.R., Kuo, W.H., Hsieh, Y.S., Yang, S.F., Li, M.L., Lin, C.C., Lian, J.D.*, and  Chu, S.C.* (2008) Circulating matrix metalloproteinase-2 is associated with cystatin C level, post-transplant duration, and diabetes mellitus in kidney transplant recipients. Translational Research 151: 2 17-23. (SCI)

55

Yang, S.F., Yang, W.E., Chang, H.R., Chu, S.C. , and Hsieh, Y.S.* (2008) Luteolin induces apoptosis in oral squamous cancer cells. Journal of Dental Research 87: 401-406. (SCI)

56

Hsieh, Y.S., Yang, S.F., Chu, S.C. , Ho, Y.J., Kuo, C.S., and Kuo, D.Y*. (2008) Transcriptional interruption of cAMP response element binding protein modulates superoxide dismutase and neuropeptide Y-mediated feeding behavior in freely moving rats. Journal of Neurochemistry 105:1438-1449. (SCI)

57

Kuo, D.Y., Yang, S.F., Chu, S.C., Chen, C.H., and Hsieh, Y.S. (2009) Roles of protein kinase Calpha isozyme in the regulation of oxidative stress and neuropeptide Y gene expression in phenylpropanolamine-mediated appetite suppression. Journal of Neurochemistry 108:1495-1506. (SCI)

58

Chen, K.S., Hsiao, Y.C., Kuo, D.Y., Chou, M.C., Chu, S.C. , Hsieh, Y.S*., and Lin, T.H*. (2009) Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells. Leukmia Research 33:297-307. (SCI)

59

Wong, B.S., Hsiao, Y.C., Lin, T.W., Chen, K.S., Chen, P.N., Kuo, W.H., Chu , S.C*. and Hsieh, Y.S*. (2009) The in vitro and in vivo apoptotic effects of Mahonia oiwakensis on human lung cancer cells.  Chemico-Biological Interactions 180: 165-174. (SCI)

60

Kuo, D.Y., Yang, S.F., Chu, S.C.*, Chu, S.C. , Chen, C.H., and Hsieh, Y.S*. (2009) Amphetamine-evoked changes of oxidative stress and neuropeptide Y gene expression in hypothalamus: Regulation by the protein kinase C-δ signaling. Chemico-Biological Interactions 180: 193-201. (SCI)

61

Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases. Yang, S.F., Chen, M.K., Hsieh, Y.S., Yang, J.S., Athanasios-I Zavras, A.I., Hsieh, Y.H., Su, S.C., Kao, T.Y., Chen P.N. and Chu, S.C.* (2010) Food and Chemical Toxicology 48:1052-4058. (SCI)

62

Ho, M.L., Chen, P.N., Chu, S.C. , Kuo, D.Y., Kuo, W.H., Chen, J.Y. and Hsieh, Y.S.* (2010) Peonidin 3-glucoside inhibit lung cancer metastasis by   down-regulation of proteinases activities and MAPK pathway. Nutrition and Cancer 62:505-516. (SCI)

63

Kuo, D.Y., Yang, S.F., Chu, S.C., Chen, C.H., Chen, P.N.*, and Hsieh, Y.S.* (2010) The effect of protein kinase C-delta knockdown on anti-free radical enzyme and neuropeptide Y gene expression in phenylpropanolamine-treated rats. Journal of Neurochemistry 114:1217-1230. (SCI)

64

Chu, S.C., Yang, S.F., Tzang, B.S., Hsieh, Y.S., Lue, K.H. and Lu, K.H. (2010) Cathepsin B and cystatin C play an inflammatory role in gouty arthritis of the knee. Clin Chim Acta. 411:1788-1792. (SCI)

65

Yang, S.F., Chen, M.K., Hsieh, Y.S., Yang, J.S., Zavras, A.I., Hsieh, Y.H., Su, S.C., Kao, T.Y., Chen, P.N. and  Chu, S.C*. (2010) Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases. Food Chem Toxicol. 48(4):1052-8. (SCI)

66

Hsieh, Y.S., Yang, S.F., Chen, P.N., Chu, S.C., Chen, C.H., Kuo, D.Y. (2011) Knocking down the transcript of protein kinase C-lambda modulates hypothalamic glutathione peroxidase, melanocortin receptor and neuropeptide Y gene expression in amphetamine-treated rats. Journal of Psychopharmacology 25:982-994. (SCI)

67

Kuo, D.Y., Chen, P.N., Yang, S.F., Chu, S.C., Chen, C.H., Kuo, M.H., Yu, C.H.*, and Hsieh, Y.S.* (2011) Role of reactive oxygen species-related enzymes in neuropeptide Y and proopiomelanocortin-mediated appetite control: A study using atypical protein kinase C knockdown. Antioxidants & Redox Signaling 15:2147-2159. (SCI)

68

Chang, H.R., Chen, P.N., Yang, S.F., Sun, Y.S., Wu, S.W., Hung, T.W., Lian, J.D., Chu, S.C. and Hsieh, Y.S*. (2011) Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel. Molecular Carcinogenesis 50:811-823. (SCI)

69

Chen, P.N., Chu, S.C., Kuo, W.H., Chou, M.Y., Lin, J.K.*, and Hsieh, Y.S.* (2011) Epigallocatechin-3 gallate inhibits invasion, epithelial-mesenchymal transition, and tumor growth in oral cancer cells. Journal of Agricultural and Food Chemistry 59:3836-3844. (SCI)

70

Lin, H.L., Ueng, K.C., Hsieh, Y.S., Chiang, W.L., Yang, S.F. and Chu, S.C*. (2012) Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility. Molecular Biology Reports 39:9023-9030. (SCI)

71

Kuo, D.Y., Chen, P.N., Yu, C.H., Kuo, M.H., Hsieh, Y.S. and Chu, S.C*. (2012) Involvement of neuropeptide Y Y1 receptor in the regulation of amphetamine-mediated appetite suppression. Neuropharmacology  63:842-850. (SCI)

72

Kuo, D.Y., Chen, P.N., Kuo, M.H., Chen, C.H., Hsieh, Y.S. and Chu, S.C*. (2012) NF-κB knockdown can modulate amphetamine-mediated feeding response. Neuropharmacology  62:1684-1694. (SCI)

73

Tseng, H.H., Chen, P.N., Kuo, W.H., Wang, J.W., Chu, S.C. and Hsieh, Y.S*. (2012) Antimetastatic potentials of Phyllanthus urinaria L on A549 and Lewis lung carcinoma cells via repression of matrix-degrading proteases. Integrative Cancer Therapies 11:267-278. (SCI)

74

Kuo, D.Y., Chen, P.N., Chu, S.C. and Hsieh, Y.S*. (2012) Knocking down the transcript of NF-kappaB modulates the reciprocal regulation of endogenous antioxidants and feeding behavior in phenylpropanolamine-treated rats. Archives Toxicology 86:453-463. (SCI)

75

Chang, Y.C., Chen, P.N., Chu, S.C., Lin, C.Y., Kuo, W.H. and Hsieh, Y.S. (2012) Black tea polyphenols reverse epithelial-to-mesenchymal transition and suppress cancer invasion and proteases in human oral cancer cells. Journal of Agricultural and Food Chemistry (In Press) (SCI)

B. 專利

1.

 Lin, J.Y., Hsieh, Y.S. and Chu, S.C. (1988) The isolation and purification of pre-S2 containing hepatitis B virus surface antigen by chemical affinity chromatography. Patent No.:USA-4855055  

C. 計畫